Processes for preparing amines and catalysts for use therein

ABSTRACT

Processes for preparing an amine, which processes comprise: reacting a reactant selected from the group consisting of primary alcohols, secondary alcohols, aldehydes, ketones, and mixtures thereof, with hydrogen and a nitrogen compound selected from the group consisting of ammonia, primary amines, secondary amines and mixtures thereof, in the presence of a zirconium dioxide-, copper- and nickel-containing catalyst; wherein the catalyst comprises a catalytically active composition which comprises, before reduction with hydrogen, oxygen compounds of zirconium, copper, and nickel, and 0.2 to 40% by weight of an oxygen compound of cobalt, calculated as CoO, 0.1 to 5% by weight of an oxygen compound of iron, calculated as Fe 2 O 3 , and 0.1 to 5% by weight of at least one oxygen compound of lead, tin, bismuth or antimony, calculated as PbO, SnO, Bi 2 O 3  and Sb 2 O 3  respectively.

CROSS-REFERENCE TO RELATED APPLICATIONS

This application is a national stage application, under 35 U.S.C. §371, of PCT/EP2008/067184, filed Dec. 10, 2008, which claims benefit of European Patent Application No. 07150407.0, filed Dec. 21, 2007, and European Patent Application No. 08166388.2, filed Oct. 10, 2008.

BACKGROUND OF THE INVENTION

The process products find use, inter alia, as intermediates in the preparation of fuel additives (U.S. Pat. No. 3,275,554 A; DE 21 25 039 A and DE 36 11 230 A), surfactants, medicaments and crop protectants, hardeners for epoxy resins, catalysts for polyurethanes, intermediates for preparing quaternary ammonium compounds, plasticizers, corrosion inhibitors, synthetic resins, ion exchangers, textile assistants, dyes, vulcanization accelerants and/or emulsifiers.

WO 06/069673 A1 (BASF AG) relates to a process for direct amination of hydrocarbons (e.g. benzene), to catalysts which are used in the direct amination and to a process for preparing these catalysts.

In the catalysts, the following metals or metal combinations are preferred: Ni, Co, Mn, Fe, Ru, Ag and/or Cu (cf. page 4, lines 10-14).

U.S. Pat. No. 4,153,581 (Habermann) relates to the amination of alcohols, aldehydes or ketones by means of specific Co/Cu catalysts which comprise Fe, Zn and/or Zr.

U.S. Pat. No. 4,152,353 (Dow) relates to the amination of alcohols, aldehydes or ketones by means of specific Ni/Cu catalysts, which comprise Fe, Zn and/or Zr.

EP 382 049 A1 (BASF AG) discloses catalysts which comprise oxygen-containing zirconium, copper, cobalt and nickel compounds, and processes for the hydrogenating amination of alcohols. The preferred zirconium oxide content of these catalysts is from 70 to 80% by weight (loc. cit.: page 2, last paragraph; page 3, 3rd paragraph; examples). Although these catalysts feature good activity and selectivity, they exhibit lifetimes in need of improvement.

EP 963 975 A1 and EP 1 106 600 A2 (both BASF AG) describe processes for preparing amines from, respectively, alcohols and aldehydes or ketones, and nitrogen compounds using a catalyst whose catalytically active composition comprises 22-40% by weight (or 22-45% by weight) of oxygen compounds of zirconium, 1-30% by weight of oxygen compounds of copper and in each case 15-50% by weight (or 5-50% by weight) of oxygen compounds of nickel and cobalt.

WO 03/076386 A and EP 1 431 271 A1 (both BASF AG) also teach catalysts of the abovementioned type for aminations.

WO 03/051508 A1 (Huntsman Petrochemical Corp.) relates to processes for aminating alcohols using specific Cu/Ni/Zr/Sn catalysts which, in a further embodiment, comprise Cr in place of Zr (see page 4, lines 10-16). The catalysts described in this WO application do not comprise any cobalt.

WO 2007/036496 A (BASF AG) describes a process for preparing aminodiglycol (ADG) and morpholine by reacting diethylene glycol (DEG) with ammonia in the presence of a heterogeneous transition metal catalyst, the catalytically active composition of the catalyst, before the treatment with hydrogen, comprising oxygen compounds of aluminum and/or zirconium, copper, nickel and cobalt, and the shaped catalyst body having specific dimensions.

Five patent applications with filing date Jul. 14, 2006 (all BASF AG), file references EP 06117249.0, 06117251.6, 06117253.2, 06117259.9 and 06117243.3 (WO 2008/006750 A, WO 2008/006748 A, WO 2008/006752 A, WO 2008/006749 A, WO 2008/006754 A) relate to particular doped zirconium dioxide-, copper- and nickel-containing catalysts and to their use in processes for preparing an amine by reacting a primary or secondary alcohol, aldehyde and/or ketone with hydrogen and ammonia, a primary or secondary amine.

The catalysts described in applications 06117249.0, 06117251.6, 06117253.2 comprise from 10 to 50% by weight, preferably from 16 to 35% by weight, of Co.

Six parallel European patent applications with the same filing date (all BASF AG) relate to particular zirconium dioxide- and nickel-containing catalysts and to their use in processes for preparing an amine by reacting a primary or secondary alcohol, aldehyde and/or ketone with hydrogen and ammonia or a primary or secondary amine.

When the very active catalysts of the prior art are used, including in particular the catalysts according to EP 963 975 A1 and EP 1 106 600 A2 (see above), there may be an increased tendency to decarbonylation of the carbonyl function (which may have formed as an intermediate) at elevated temperature in the reactants (alcohols, aldehydes, ketones). The formation of methane by hydrogenation of carbon monoxide (CO) leads, owing to the large amount of heat of hydrogenation released, to a “runaway risk”, i.e. an uncontrolled temperature rise in the reactor. When CO is scavenged by amines, methyl-containing secondary components are formed.

In the amination of diethylene glycol (DEG), there is, for example, an increased tendency to form undesired methoxyethanol or methoxyethylamine. Methoxyethanol is toxic, can be removed from morpholine only with difficulty owing to its physical properties and can thus lead to problems with regard to specification and product quality.

In the case of the example of the amination of diethylene glycol (DEG), the “decarbonylation” is viewed in particular as the sum of undesired components (methanol, methoxyethanol, methoxyethylamine, N-methylmorpholine and methoxy-ethylmorpholine) which are formed from DEG via methoxyethanol according to the reaction network:

The reaction mechanism of the amination of primary or secondary alcohols is assumed to be that the alcohol is initially dehydrogenated to the corresponding aldehyde at a metal site. In this reaction, the copper or else nickel is suspected to be of particular significance as a dehydrogenation component. When aldehydes are used for the amination, this step is not needed.

The aldehyde formed or used can be aminated by reaction with ammonia or primary or secondary amine with elimination of water and subsequent hydrogenation. This condensation of the aldehyde with the abovementioned nitrogen compound is suspected to be catalyzed by acidic sites of the catalyst. In an undesired side reaction, the aldehyde can also be decarbonylated, i.e. in that the aldehyde function is eliminated as CO. The decarbonylation or methanization is suspected to take place at a metallic site. The CO is hydrogenated to methane over the hydrogenation catalyst, so that the methane formation indicates the extent of decarbonylation. The decarbonylation forms the abovementioned undesired by-products, for example methoxyethanol and/or methoxyethylamine in the abovementioned case.

The desired condensation of the aldehyde with ammonia or primary or secondary amine and the undesired decarbonylation of the aldehyde are parallel reactions, of which the desired condensation is suspected to be acid-catalyzed, while the undesired decarbonylation is catalyzed by metallic sites.

BRIEF SUMMARY OF THE INVENTION

The present invention relates to zirconium dioxide-, copper- and nickel-containing catalysts and to a process for preparing an amine by reacting a primary or secondary alcohol, aldehyde and/or ketone with hydrogen and a nitrogen compound selected from the group of ammonia, primary and secondary amines, in the presence of a zirconium dioxide-, copper- and nickel-containing catalyst.

It was an object of the present invention to improve the economic viability of existing processes for hydrogenating amination of aldehydes or ketones and the amination of alcohols, and to remedy one or more disadvantages of the prior art, especially the abovementioned disadvantages. The intention was to find catalysts which can be prepared industrially in a simple manner and which enable the above-mentioned aminations to be performed with high conversion, high yield, space-time yields (STY), selectivity, catalyst lifetime with simultaneously high mechanical stability of the shaped catalyst body and low “runaway risk”. The catalysts should accordingly have a high activity and have high chemical and mechanical stability under the reaction conditions. Furthermore, the use of the catalysts in corresponding amination processes in which, owing to the chemical structure of the reactants, linear and cyclic process products can result should lead to the linear process product(s) with improved selectivity.

[Space-time yields are reported in “amount of product/(catalyst volume·time)” (kg/(I_(cat)·h)) and/or “amount of product/(reactor volume·time)’ (kg/(I_(reactor)·h)].

Accordingly, we have found a process for preparing an amine by reacting a primary or secondary alcohol, aldehyde and/or ketone with hydrogen and a nitrogen compound selected from the group of ammonia, primary and secondary amines, in the presence of a zirconium dioxide-, copper- and nickel-containing catalyst, wherein the catalytically active composition of the catalyst, before its reduction with hydrogen, comprises oxygen compounds of zirconium, of copper, of nickel, in the range from 0.2 to 40% by weight, preferably from 1 to 25% by weight, more preferably from 2 to 10% by weight, of oxygen compounds of cobalt, calculated as CoO, in the range from 0.1 to 5% by weight, preferably from 0.2 to 4% by weight, more preferably from 0.5 to 3% by weight, of oxygen compounds of iron, calculated as Fe₂O₃, and in the range from 0.1 to 5% by weight, preferably from 0.3 to 4.5% by weight, more preferably from 0.5 to 4% by weight, of oxygen compounds of lead, of tin, of bismuth and/or of antimony calculated in each case as PbO, SnO, Bi₂O₃, and Sb₂O₃ respectively.

We have also found catalysts whose catalytically active composition, before its reduction with hydrogen, comprises oxygen compounds of zirconium, of copper, of nickel, in the range from 0.2 to 40% by weight, preferably from 1 to 25% by weight, more preferably from 2 to 10% by weight, of oxygen compounds of cobalt, calculated as CoO, in the range from 0.1 to 5% by weight, preferably from 0.2 to 4% by weight, more preferably from 0.5 to 3% by weight, of oxygen compounds of iron, calculated as Fe₂O₃, and in the range from 0.1 to 5% by weight, preferably from 0.3 to 4.5% by weight, more preferably from 0.5 to 4% by weight, of oxygen compounds of lead, of tin, of bismuth, and/or of antimony, calculated in each case as PbO, SnO, Bi₂O₃, and Sb₂O₃ respectively.

More particularly, we have found catalysts whose catalytically active composition, before their reduction with hydrogen, comprises in the range from

-   20 to 85% by weight of oxygen compounds of zirconium, calculated as     ZrO₂, -   0.2 to 25% by weight of oxygen compounds of copper, calculated as     CuO, -   0.2 to 45% by weight of oxygen compounds of nickel, calculated as     NiO, and -   0.2 to 40% by weight, preferably 1 to 25% by weight, more preferably     2 to 10% by weight, of oxygen compounds of cobalt, calculated as     CoO, -   0.1 to 5% by weight, preferably 0.2 to 4% by weight, more preferably     0.5 to 3% by weight, of oxygen compounds of iron, calculated as     Fe₂O₃, and -   0.1 to 5.0% by weight, preferably 0.3 to 4.5% by weight,     particularly 0.5 to 4% by weight, of oxygen compounds of lead, of     tin, of bismuth, and/or of antimony, calculated in each case as PbO,     SnO, Bi₂O₃, and Sb₂O₃ respectively, and their use in the     abovementioned amination process, especially in the process for     reacting DEG with ammonia.

Among the abovementioned dopant components Pb, Sn, Bi, and Sb, Pb (lead) is particularly preferred.

In a very particularly preferred embodiment, the catalytically active composition of the inventive catalyst or that used in the process according to the invention, before its reduction with hydrogen, comprises in the range from

-   2 to 10% by weight of oxygen compounds of cobalt, calculated as CoO,     and -   0.1 to 5.0% by weight, preferably 0.3 to 4.5% by weight,     particularly 0.5 to 4% by weight, of oxygen compounds of lead,     calculated as PbO.

All data regarding the catalytically active composition of the inventive catalysts and of the catalysts used in the process according to the invention are based on the catalytically active composition before its reduction with hydrogen.

DETAILED DESCRIPTION OF THE INVENTION

In accordance with the invention, it has been recognized that the activity of the catalyst for the amination of primary or secondary alcohols, aldehydes and/or ketones in the presence of H₂, for example the amination of diethylene glycol (DEG) with ammonia to give aminodiglycol and morpholine, as a result of the specific content in the zirconium-copper-nickel catalysts of cobalt and iron and the additional content of lead, tin, bismuth and/or antimony, essentially at least remains constant, but the extent of the undesired decarbonylation reaction simultaneously decreases and hence the selectivity of the amination reaction increases.

The process can be performed continuously or batchwise. Preference is given to a continuous method.

For the synthesis in the gas phase, the reactants are fed to the reactor in a controlled manner, preferably in a cycle gas stream, evaporated and in gaseous form. Suitable amines for a gas phase synthesis are amines which, owing to their boiling points and the boiling points of their reactants, can be kept in the gas phase within the process parameters by process technology means. The cycle gas serves firstly to evaporate the reactants and secondly as a reactant for the amination.

In the cycle gas method, the starting materials (alcohol, aldehyde and/or ketone, hydrogen and the nitrogen compound) are evaporated in a cycle gas stream and fed to the reactor in gaseous form.

The reactants (alcohol, aldehyde and/or ketone, the nitrogen compound) may also be evaporated as aqueous solutions and passed to the catalyst bed with the cycle gas stream.

Preferred reactors are tubular reactors. Examples of suitable reactors with cycle gas stream can be found in Ullmann's Encyclopedia of Industrial Chemistry, 5th Ed., Vol. B 4, pages 199-238, “Fixed-Bed Reactors”.

Alternatively, the reaction is advantageously effected in a tube bundle reactor or in a single-stream plant.

In a single-stream plant, the tubular reactor in which the reaction proceeds can consist of a series connection of a plurality of (e.g. two or three) individual tubular reactors. Optionally, an intermediate introduction of feed (comprising the reactant and/or ammonia and/or H₂) and/or cycle gas and/or reactor effluent from a downstream reactor is possible here in an advantageous manner.

The cycle gas flow rate is preferably in the range from 40 to 1500 m³ (at operating pressure)/[m³ of catalyst (bed volume)·h], in particular in the range from 100 to 700 m³ (at operating pressure)/[m³ of catalyst (bed volume)·h].

The cycle gas comprises preferably at least 10% by volume, particularly from 50 to 100% by volume, very particularly from 80 to 100% by volume of H₂.

For the synthesis in the liquid phase, suitable reactants and products are all of those which have high boiling points or are thermally labile. In these cases, a further advantage is that it is possible to dispense with evaporation and recondensation of the amine in the process.

In the process according to the invention, the catalysts are preferably used in the form of catalysts which consist only of catalytically active composition and, if appropriate, a shaping assistant (for example graphite or stearic acid) if the catalyst is used as a shaped body, i.e. do not comprise any further catalytically active ingredients.

In this connection, the oxidic support material zirconium dioxide (ZrO₂) is considered to be included in the catalytically active composition.

The catalysts are used in such a way that the catalytically active composition ground to powder is introduced into the reaction vessel or that the catalytically active composition, after grinding, mixing with shaping assistants, shaping and heat treatment, is arranged in the reactor as shaped catalyst bodies—for example as tablets, spheres, rings, extrudates (e.g. strands).

The concentration data (in % by weight) of the components of the catalyst are based in each case, unless stated otherwise, on the catalytically active composition of the finished catalyst after its last heat treatment and before its reduction with hydrogen.

The catalytically active composition of the catalyst, after its last heat treatment and before its reduction with hydrogen, is defined as the sum of the masses of the catalytically active constituents and of the abovementioned catalyst support materials, and comprises essentially the following constituents:

zirconium dioxide (ZrO₂), oxygen compounds of copper, nickel and cobalt and iron and oxygen compounds of lead, of tin, of bismuth and/or of antimony.

The sum of the abovementioned constituents of the catalytically active composition is typically from 70 to 100% by weight, preferably from 80 to 100% by weight, more preferably from 90 to 100% by weight, particularly >95% by weight, very particularly >98% by weight, in particular >99% by weight, for example more preferably 100% by weight.

The catalytically active composition of the inventive catalysts and those used in the process according to the invention may also comprise one or more elements (oxidation stage 0) or their inorganic or organic compounds selected from groups I A to VI A and I B to VII B and VIII of the Periodic Table of the Elements.

Examples of such elements and their compounds are:

transition metals such as Mn or MnO₂, W or tungsten oxides, Ta or tantalum oxides, Nb or niobium oxides or niobium oxalate, V or vanadium oxides or vanadyl pyrophosphate; lanthanides such as Ce or CeO₂, or Pr or Pr₂O₃; alkali metal oxides such as Na₂O; alkali metal carbonates such as Na₂CO₃; alkaline earth metal oxides such as SrO; alkaline earth metal carbonates such as MgCO₃, CaCO₃ and BaCO₃; boron oxide (B₂O₃).

The catalytically active composition of the inventive catalysts and those used in the process according to the invention preferably does not comprise any rhenium, any ruthenium and/or any zinc, in each case either in metallic (oxidation state 0) form or in an ionic, especially oxidized, form.

The catalytically active composition of the inventive catalysts and of those used in the process according to the invention preferably does not comprise any silver and/or molybdenum, in each case either in metallic (oxidation state 0) form or in an ionic, especially oxidized, form.

In a particularly preferred embodiment, the catalytically active composition of the inventive catalysts and of those used in the process according to the invention does not comprise any further catalytically active component, either in elemental or in ionic form. In the particularly preferred embodiment, the catalytically active composition is not doped with further metals or metal compounds.

Preferably, however, typical accompanying trace elements originating from the metal extraction of Cu, Co, Ni, Pb, Sn, Bi, Sb are excluded therefrom.

The catalytically active composition of the catalyst, before its reduction with hydrogen comprises, in the range from 0.2 to 40% by weight, particularly in the range from 1 to 25% by weight, more particularly in the range from 2 to 10% by weight, of oxygen compounds of cobalt, calculated as CoO.

The catalytically active composition of the catalyst comprises, before its reduction with hydrogen, in the range from 0.1 to 5% by weight, particularly in the range from 0.2 to 4% by weight, more particularly in the range from 0.5 to 3% by weight, of oxygen compounds of iron, calculated as Fe₂O₃.

In addition, the catalytically active composition of the catalyst, before its reduction with hydrogen, comprises preferably in the range from

-   20 to 85% by weight, particularly from 25 to 70% by weight, more     particularly from 30 to 60% by weight, of oxygen compounds of     zirconium, calculated as ZrO₂, -   0.2 to 25% by weight, particularly from 3 to 20% by weight, more     particularly from 5 to 15% by weight, of oxygen compounds of copper,     calculated as CuO, -   0.2 to 45% by weight, particularly from 10 to 40% by weight, more     particularly from 25 to 35% by weight, of oxygen compounds of     nickel, calculated as NiO, and -   0.1 to 5.0% by weight, particularly from 0.3 to 4.5% by weight, more     particularly from 0.5 to 4% by weight, of oxygen compounds of lead,     of tin, of bismuth and/or of antimony, calculated in each case as     PbO, SnO, Bi₂O₃ and Sb₂O₃ respectively.

The molar ratio of nickel to copper is preferably greater than 1, more preferably greater than 1.2 and even more preferably in the range from 1.8 to 8.5.

To prepare the catalysts used in the process according to the invention, various processes are possible. They are, for example, obtainable by peptizing pulverulent mixtures of the hydroxides, carbonates, oxides and/or other salts of the components with water and subsequently extruding and heat-treating the composition thus obtained.

Preference is given to preparing the inventive catalysts by employing precipitation methods. For example, they can be obtained by coprecipitating the nickel, cobalt and copper and iron and doping components from an aqueous salt solution comprising these elements by means of bases in the presence of a slurry of a sparingly soluble, oxygen-containing zirconium compound and subsequently washing, drying and calcining the resulting precipitate. The sparingly soluble oxygen-containing zirconium compounds used may, for example, be zirconium dioxide, zirconium oxide hydrate, zirconium phosphates, zirconium borates and zirconium silicates. The slurries of the sparingly soluble zirconium compounds can be prepared by suspending fine powders of these compounds in water with vigorous stirring. Advantageously, these slurries are obtained by precipitating the sparingly soluble zirconium compounds from aqueous zirconium salt solutions by means of bases.

The inventive catalysts are preferably prepared by means of a coprecipitation (mixed precipitation) of all of their components. To this end, an aqueous salt solution comprising the catalyst components is appropriately admixed with an aqueous base—for example sodium carbonate, sodium hydroxide, potassium carbonate or potassium hydroxide—under hot conditions with stirring until the precipitation is complete. It is also possible to work with alkali metal-free bases such as ammonia, ammonium carbonate, ammonium hydrogencarbonate, ammonium carbamate, ammonium oxalate, ammonium malonate, urotropin, urea, etc. The type of salts used is generally not critical: since the principal factor in this procedure is the water solubility of the salts, a criterion is their good water solubility required to prepare these comparatively highly concentrated salt solutions. It is considered to be self-evident that, when selecting the salts of the individual components, the salts selected will of course only be those with anions which do not lead to disruption, whether by causing undesired precipitations or by complicating or preventing the precipitation by complex formation.

The precipitates obtained in these precipitation reactions are generally chemically inhomogeneous and consist, inter alia, of mixtures of the oxides, oxide hydrates, hydroxides, carbonates and insoluble and basic salts of the metals used. It may be found to be favorable for the filterability of the precipitates when they are aged, i.e. when they are left for a certain time after the precipitation, if appropriate under hot conditions or while passing air through.

The precipitates obtained by these precipitation processes are processed further as usual to give the inventive catalysts. First, the precipitates are washed. The content of alkali metal which has been supplied by the (mineral) base which may have been used as a precipitant can be influenced via the duration of the washing operation and via the temperature and amount of the washing water. In general, prolonging the washing time or increasing the temperature of the washing water will decrease the content of alkali metal. After the washing, the precipitated material is generally dried at from 80 to 200° C., preferably at from 100 to 150° C., and then calcined. The calcination is performed generally at temperatures between 300 and 800° C., preferably at from 400 to 600° C., in particular at from 450 to 550° C.

The inventive catalysts may also be prepared by impregnating zirconium dioxide (ZrO₂) which is present, for example, in the form of powder or shaped bodies such as extrudates, tablets, spheres or rings.

The zirconium dioxide is used, for example, in the amorphous, monoclinic or tetragonal form, preferably in the monoclinic form.

Shaped bodies can be produced by the customary processes.

The impregnation is likewise effected by the customary processes, as described, for example, in A. B. Stiles, Catalyst Manufacture—Laboratory and Commercial Preparations, Marcel Dekker, New York (1983), by applying an appropriate metal salt solution in each case in one or more impregnation stages, the metal salts used being, for example, appropriate nitrates, acetates or chlorides. After the impregnation, the composition is dried and optionally calcined.

The impregnation can be effected by the so-called incipient wetness method, in which the zirconium dioxide is moistened, in accordance with its water uptake capacity, up to a maximum of saturation with the impregnation solution. The impregnation can also be effected in supernatant solution.

In the case of multistage impregnation processes, it is appropriate to dry and optionally to calcine between individual impregnation steps. Multistage impregnation can be employed particularly advantageously when the zirconium dioxide is to be loaded with a relatively large amount of metal.

To apply the metal components to the zirconium dioxide, the impregnation can be effected simultaneously with all metal salts or successively in any sequence of the individual metal salts.

Subsequently, the catalysts prepared by impregnation are dried and preferably also calcined, for example within the calcination temperature ranges already specified above.

After the calcination, the catalyst is appropriately conditioned, whether it be by grinding to a certain particle size or by mixing it, after it has been ground, with shaping assistants such as graphite or stearic acid, compressing it by means of a press to moldings, for example tablets, and heat-treating. The heat treatment temperatures correspond preferably to the temperatures in the calcining.

The catalysts prepared in this way comprise the catalytically active metals in the form of a mixture of their oxygen compounds, i.e. in particular in the form of oxides and mixed oxides.

The catalysts prepared, for example, as described above are stored as such and, if appropriate, treated. Before they are used as catalysts, they are typically prereduced.

However, they can also be used without prereduction, in which case they are reduced under the conditions of the hydrogenating amination by the hydrogen present in the reactor.

For prereduction, the catalysts are exposed to a nitrogen-hydrogen atmosphere first at preferably from 150 to 200° C. over a period of, for example, from 12 to 20 hours, and then treated in a hydrogen atmosphere at preferably from 200 to 400° C. for another up to approx. 24 hours. This prereduction reduces a portion of the oxygen-containing metal compounds present in the catalysts to the corresponding metals, so that they are present together with the different types of oxygen compounds in the active form of the catalyst.

A further advantage of the inventive catalysts is their mechanical stability, i.e. their hardness. The mechanical stability can be determined by the measurement of the so-called side crushing strength. For this purpose, the shaped catalyst body, for example the catalyst tablet, is stressed with increasing force between two parallel plates until fracture of the shaped catalyst body occurs, and this stress may act, for example, on the cylindrical surface of catalyst tablets. The force registered when the shaped catalyst body fractures is the side crushing strength.

The process according to the invention is preferably performed continuously, the catalyst preferably being arranged in the reactor as a fixed bed. It is possible for the flow toward the fixed catalyst bed to be either from the top or from the bottom. The gas stream is adjusted in terms of temperature, pressure and flow rate in such a way that even relatively high-boiling reaction products remain in the gas phase.

The aminating agent may, with regard to the alcoholic hydroxyl group or aldehyde group or keto group to be aminated, be used in stoichiometric, sub- or superstoichiometric amounts.

In the case of the amination of alcohols, aldehydes or ketones with primary or secondary amines, the amine is preferably used in an approximately stoichiometric amount or slightly superstoichiometric amount per mole of alcoholic hydroxyl group, aldehyde group or keto group to be aminated.

The amine component (nitrogen compound) is used preferably in from 0.90 to 100 times the molar amount, especially in from 1.0 to 10 times the molar amount, based in each case on the alcohol, aldehyde and/or ketone used.

Especially ammonia is used generally with a from 1.5- to 250-fold, preferably from 2- to 100-fold, especially from 2- to 10-fold molar excess per mole of alcoholic hydroxyl group, aldehyde group or keto group to be converted.

Higher excesses both of ammonia and of primary or secondary amines are possible.

Preference is given to employing an offgas flow rate of from 5 to 800 standard cubic meters/h, especially from 20 to 300 standard cubic meters/h.

The amination of the primary or secondary alcohol groups, aldehyde groups or keto groups of the reactant can be performed in the liquid phase or in the gas phase. Preference is given to the fixed bed process in the gas phase.

When working in the liquid phase, the reactants (alcohol, aldehyde or ketone plus ammonia or amine) are passed simultaneously, including hydrogen, over the catalyst, which is typically disposed in a fixed bed reactor preferably heated externally, in the liquid phase at pressures of generally from 5 to 30 MPa (50-300 bar), preferably from 5 to 25 MPa, more preferably from 15 to 25 MPa, and temperatures of generally from 80 to 350° C., particularly from 100 to 300° C., preferably from 120 to 270° C., more preferably from 130 to 250° C., in particular from 170 to 230° C. Both a trickle mode and a liquid-phase mode are possible. The catalyst hourly space velocity is generally in the range from 0.05 to 5 kg, preferably from 0.1 to 2 kg and more preferably from 0.2 to 0.6 kg of alcohol, aldehyde or ketone per liter of catalyst (bed volume) and hour. If appropriate, the reactants can be diluted with a suitable solvent such as tetrahydrofuran, dioxane, N-methylpyrrolidone or ethylene glycol dimethyl ether. It is appropriate to heat the reactants before they are fed into the reaction vessel, preferably to the reaction temperature.

When working in the gas phase, the gaseous reactants (alcohol, aldehyde or ketone plus ammonia or amine) are passed over the catalyst in the presence of hydrogen in a gas stream, preferably hydrogen, selected so as to be sufficiently large for evaporation, at pressures of generally from 0.1 to 40 MPa (from 1 to 400 bar), preferably from 0.1 to 10 MPa, more preferably from 0.1 to 5 MPa. The temperatures for the amination of alcohols are generally from 80 to 350° C., particularly from 100 to 300° C., preferably from 120 to 270° C., more preferably from 160 to 250° C. The reaction temperatures in the hydrogenating amination of aldehydes and ketones are generally from 80 to 350° C., particularly from 90 to 300° C., preferably from 100 to 250° C. The flow to the fixed catalyst bed may be either from above or from below. The required gas stream is preferably obtained by a cycle gas method.

The catalyst hourly space velocity is generally in the range from 0.01 to 2 and preferably from 0.05 to 0.5 kg of alcohol, aldehyde or ketone per liter of catalyst (bed volume) and hour.

The hydrogen is fed to the reaction generally in an amount of from 5 to 400 l, preferably in an amount of from 50 to 200 l per mole of alcohol, aldehyde or ketone component, the amounts in liters each having been converted to standard conditions (S.T.P.). The performance of the amination of aldehydes or ketones differs from that of the amination of alcohols in that at least stoichiometric amounts of hydrogen need to be present in the amination of aldehydes and ketones.

Both in the case of operation in the liquid phase and in the case of operation in the gas phase, it is possible to use higher temperatures and higher overall pressures and catalyst hourly space velocities. The pressure in the reaction vessel, which results from the sum of the partial pressures of the aminating agent, of the alcohol, aldehyde or ketone, and of the reaction products formed and, if appropriate, of the solvent used at the temperatures specified, is appropriately increased by injecting hydrogen up to the desired reaction pressure.

Both in the case of continuous operation in the liquid phase and in the case of continuous operation in the gas phase, the excess aminating agent can be circulated together with the hydrogen.

When the catalyst is arranged as a fixed bed, it may be advantageous for the selectivity of the reaction to mix the shaped catalyst bodies in the reactor with inert packings, to “dilute” them as it were. The proportion of packings in such catalyst preparations may be from 20 to 80 parts by volume, particularly from 30 to 60 parts by volume and in particular from 40 to 50 parts by volume.

The water of reaction formed in the course of the reaction (in each case one mole per mole of alcohol group, aldehyde group or keto group converted) generally does not have a disruptive effect on the degree of conversion, the reaction rate, the selectivity and the catalyst lifetime, and is therefore appropriately not removed therefrom until the workup of the reaction product, for example by distillation.

After the reaction effluent has appropriately been decompressed, the excess hydrogen and any excess aminating agent present are removed therefrom and the resulting crude reaction product is purified, for example by a fractional rectification. Suitable workup processes are described, for example, in EP 1 312 600 A and EP 1 312 599 A (both BASF AG). The excess aminating agent and the hydrogen are advantageously returned back into the reaction zone. The same applies to any incompletely converted alcohol, aldehyde or ketone component.

Unconverted reactants and any suitable by-products which are obtained can be returned back into the synthesis. Unconverted reactants can be flowed again in the cycle gas stream over the catalyst bed in batchwise or continuous mode after condensation of the products in the separator.

Aminating agents in the process according to the invention are, as well as ammonia, primary and secondary amines.

It is possible by the process according to the invention to prepare, for example, amines of the formula I

-   -   in which     -   R¹, R² are each hydrogen (H), alkyl such as C₁₋₂₀-alkyl,         cycloalkyl such as C₃₋₁₂-cycloalkyl, alkoxyalkyl such as         C₂₋₃₀-alkoxyalkyl, dialkylaminoalkyl such as         C₃₋₃₀-dialkylaminoalkyl, aryl, aralkyl such as C₇₋₂₀-aralkyl and         alkylaryl such as C₇₋₂₀-alkylaryl, or together are         —(CH₂)_(j)—X—(CH₂)_(k)—,     -   R³, R⁴ are each hydrogen (H), alkyl such as C₁₋₂₀-alkyl,         cycloalkyl such as C₃₋₁₂-cycloalkyl, hydroxyalkyl such as         C₁₋₂₀-hydroxyalkyl, aminoalkyl such as C₁₋₂₀-aminoalkyl,         hydroxyalkylaminoalkyl such as C₂₋₂₀-hydroxyalkylaminoalkyl,         alkoxyalkyl such as C₂₋₃₀-alkoxyalkyl, dialkylaminoalkyl such as         C₃₋₃₀-dialkylamino-alkyl, alkylaminoalkyl such as         C₂₋₃₀-alkylaminoalkyl, R⁵—(OCR⁶R⁷CR⁸R⁹)_(n)—(OCR⁶R⁷), aryl,         heteroaryl, aralkyl such as C₇₋₂₀-aralkyl, heteroarylalkyl such         as C₄₋₂₀-heteroarylalkyl, alkylaryl such as C₇₋₂₀-alkylaryl,         alkylheteroaryl such as C₄₋₂₀-alkylheteroaryl, and         Y—(CH₂)_(m)—NR⁵—(CH₂)_(q) or, together, —(CH₂)_(l)—X—(CH₂)_(m)—         or     -   R² and R⁴ together are —(CH₂)_(l)—X—(CH₂)_(m)—,     -   R⁵, R¹⁰ are each hydrogen (H), alkyl such as C₁₋₄-alkyl,         alkylphenyl such as C₇₋₄₀-alkylphenyl,     -   R⁶, R⁷, R⁸, R⁹ are each hydrogen (H), methyl or ethyl,     -   X is CH₂, CHR⁵, oxygen (O), sulfur (S) or NR⁵,     -   Y is N(R¹⁰)₂, hydroxyl, C₂₋₂₀-alkylaminoalkyl or         C₃₋₂₀-dialkylaminoalkyl,     -   n is an integer from 1 to 30 and     -   j, k, l, m, q are each integers from 1 to 4.

The process according to the invention therefore preferably finds use for preparing an amine I by reacting a primary or secondary alcohol of the formula II

and/or an aldehyde and/or a ketone of the formula VI or VII

with a nitrogen compound of the formula III

where R¹, R², R³ and R⁴ are each as defined above.

The reactant alcohol may also be an amino alcohol, for example an amino alcohol of the formula II.

As is evident from the definitions of the R² and R⁴ radicals, the reaction can also be effected intramolecularly in an appropriate amino alcohol, amino ketone or amino aldehyde.

To prepare the amine I, in a purely formal sense, a hydrogen atom of the nitrogen compound III is accordingly replaced by the R⁴(R³)CH— radical with release of one molar equivalent of water.

The process according to the invention preferably also finds use in the preparation of a cyclic amine of the formula IV

in which

-   R¹¹ and R¹² are each hydrogen (H), alkyl such as C₁- to C₂₀-alkyl,     cycloalkyl such as C₃- to C₁₂-cycloalkyl, aryl, heteroaryl, aralkyl     such as C₇- to C₂₀-aralkyl, and alkylaryl such as C₇- to     C₂₀-alkylaryl, -   Z is CH₂, CHR⁵, oxygen (O), NR⁵ or NCH₂CH₂OH and -   R¹, R⁶, R⁷ are each as defined above     by reacting an alcohol of the formula V

with ammonia or a primary amine of the formula VIII R¹—NH₂  (VIII).

The substituents R¹ to R¹², the variables X, Y, Z, and the indices j, k, l, m, n and q in the compounds I, II, III, IV, V, VI and VII are each independently defined as follows:

-   R¹, R², R³, R⁴, R⁵, R⁶, R⁷, R⁸, R⁹, R¹⁰, R¹¹, R¹²:     -   hydrogen (H), -   R³, R⁴:     -   alkyl such as C₁₋₂₀-alkyl, preferably C₁₋₁₄-alkyl, such as         methyl, ethyl, n-propyl, isopropyl, n-butyl, isobutyl,         sec-butyl, tert-butyl, n-pentyl, isopentyl, sec-pentyl,         neopentyl, 1,2-dimethylpropyl, n-hexyl, isohexyl, sec-hexyl,         cyclopentylmethyl, n-heptyl, isoheptyl, cyclohexylmethyl,         n-octyl, isooctyl, 2-ethylhexyl, n-decyl, 2-n-propyl-n-heptyl,         n-tridecyl, 2-n-butyl-n-nonyl and 3-n-butyl-n-nonyl,     -   hydroxyalkyl such as C₁₋₂₀-hydroxyalkyl, preferably         C₁₋₈-hydroxyalkyl, more preferably C₁₋₄-hydroxyalkyl, such as         hydroxymethyl, 1-hydroxyethyl, 2-hydroxy-ethyl,         1-hydroxy-n-propyl, 2-hydroxy-n-propyl, 3-hydroxy-n-propyl and         1-(hydroxy-methyl)ethyl,     -   aminoalkyl such as C₁₋₂₀-aminoalkyl, preferably C₁₋₈-aminoalkyl,         such as aminomethyl, 2-aminoethyl, 2-amino-1,1-dimethylethyl,         2-amino-n-propyl, 3-amino-n-propyl, 4-amino-n-butyl,         5-amino-n-pentyl, N-(2-aminoethyl)-2-aminoethyl and         N-(2-aminoethyl)aminomethyl,     -   hydroxyalkylaminoalkyl such as C₂₋₂₀-hydroxyalkylaminoalkyl,         preferably C₃₋₈-hydroxyalkylaminoalkyl, such as         (2-hydroxyethylamino)methyl, 2-(2-hydroxyethyl-amino)ethyl and         3-(2-hydroxyethylamino)propyl,     -   R⁵—(OCR⁶R⁷CR⁸R⁹)_(n)—(OCR⁶R⁷), preferably R⁵—(OCHR⁷CHR⁹),         —(OCR⁶R⁷), more preferably R⁵—(OCH₂CHR⁹)_(n), —(OCR⁶R⁷),     -   alkylaminoalkyl such as C₂₋₃₀-alkylaminoalkyl, preferably         C₂₋₂₀-alkylaminoalkyl, more preferably C₂₋₈-alkylaminoalkyl,         such as methylaminomethyl, 2-methyl-aminoethyl,         ethylaminomethyl, 2-ethylaminoethyl and 2-(isopropylamino)ethyl,         (R⁵)HN—(CH₂)_(q),     -   Y—(CH₂)_(m)—NR⁵—(CH₂)_(q),     -   heteroarylalkyl such as C₄₋₂₀-heteroarylalkyl, such as         pyrid-2-ylmethyl, furan-2-ylmethyl, pyrrol-3-ylmethyl and         imidazol-2-ylmethyl,     -   alkylheteroaryl such as C₄₋₂₀-alkylheteroaryl, such as         2-methyl-3-pyridinyl, 4,5-di-methylimidazol-2-yl,         3-methyl-2-furanyl and 5-methyl-2-pyrazinyl,     -   heteroaryl such as 2-pyridinyl, 3-pyridinyl, 4-pyridinyl,         pyrazinyl, pyrrol-3-yl, imidazol-2-yl, 2-furanyl and 3-furanyl, -   R¹, R², R³, R⁴:     -   cycloalkyl such as C₃₋₁₂-cycloalkyl, preferably C₃₋₈-cycloalkyl,         such as cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl,         cycloheptyl and cyclooctyl, more preferably cyclopentyl and         cyclohexyl,     -   alkoxyalkyl such as C₂₋₃₀-alkoxyalkyl, preferably         C₂₋₂₀-alkoxyalkyl, more preferably C₂₋₈-alkoxyalkyl, such as         methoxymethyl, ethoxymethyl, n-propoxymethyl, isopropoxymethyl,         n-butoxymethyl, isobutoxymethyl, sec-butoxymethyl,         tert-butoxymethyl, 1-methoxyethyl and 2-methoxyethyl, more         preferably C₂₋₄-alkoxyalkyl,     -   dialkylaminoalkyl such as C₃₋₃₀-dialkylaminoalkyl, preferably         C₃₋₂₀-dialkylamino-alkyl, more preferably         C₃₋₁₀-dialkylaminoalkyl, such as N,N-dimethylaminomethyl,         (N,N-dibutylamino)methyl, 2-(N,N-dimethylamino)ethyl,         2-(N,N-diethyl-amino)ethyl, 2-(N,N-dibutylamino)ethyl,         2-(N,N-di-n-propylamino)ethyl and 2-(N,N-diisopropylamino)ethyl,         3-(N,N-dimethylamino)propyl, (R⁵)₂N—(CH₂)_(q),     -   aryl such as phenyl, 1-naphthyl, 2-naphthyl, 1-anthryl,         2-anthryl and 9-anthryl, preferably phenyl, 1-naphthyl and         2-naphthyl, more preferably phenyl,

alkylaryl such as C₇₋₂₀-alkylaryl, preferably C₇₋₁₂-alkylphenyl, such as 2-methylphenyl, 3-methylphenyl, 4-methylphenyl, 2,4-dimethylphenyl, 2,5-dimethylphenyl, 2,6-dimethylphenyl, 3,4-dimethylphenyl, 3,5-dimethylphenyl, 2,3,4-trimethylphenyl, 2,3,5-trimethylphenyl, 2,3,6-trimethylphenyl, 2,4,6-trimethylphenyl, 2-ethylphenyl, 3-ethylphenyl, 4-ethylphenyl, 2-n-propylphenyl, 3-n-propylphenyl and 4-n-propylphenyl,

-   -   aralkyl such as C₇₋₂₀-aralkyl, preferably C₇₋₁₂-phenylalkyl,         such as benzyl, p-methoxybenzyl, 3,4-dimethoxybenzyl,         1-phenethyl, 2-phenethyl, 1-phenyl-propyl, 2-phenylpropyl,         3-phenylpropyl, 1-phenylbutyl, 2-phenylbutyl, 3-phenyl-butyl and         4-phenylbutyl, more preferably benzyl, 1-phenethyl and         2-phenethyl,     -   R³ and R⁴ or R² and R⁴ together are a —(CH₂)_(l)—X—(CH₂)_(m)—         group such as —(CH₂)₃—, —(CH₂)₄—, —(CH₂)₅—, —(CH₂)₆—, —(CH₂)₇—,         —(CH₂)—O—(CH₂)₂—, —(CH₂)—NR⁵—(CH₂)₂—, —(CH₂)—CHR⁵—(CH₂)₂—,         —(CH₂)₂—O—(CH₂)₂—, —(CH₂)₂—NR⁵—(CH₂)₂—, —(CH₂)₂—CHR⁵— (CH₂)₂—,         —CH₂—O—(CH₂)₃—, —CH₂—NR⁵—(CH₂)₃—, —CH₂—CHR⁵—(CH₂)₃—,

-   R¹, R²:     -   alkyl such as C₁₋₂₀-alkyl, preferably C₁₋₈-alkyl, such as         methyl, ethyl, n-propyl, isopropyl, n-butyl, isobutyl,         sec-butyl, tert-butyl, n-pentyl, isopentyl, sec-pentyl,         neopentyl, 1,2-dimethylpropyl, n-hexyl, isohexyl, sec-hexyl,         n-heptyl, isoheptyl, n-octyl, isooctyl, 2-ethylhexyl, more         preferably C₁₋₄-alkyl, or     -   R¹ and R² together are a —(CH₂); —X—(CH₂)_(k)— group such as         —(CH₂)₃—, —(CH₂)₄—, —(CH₂)₅—, —(CH₂)₆—, —(CH₂)₇—,         —(CH₂)—O—(CH₂)₂—, —(CH₂)—NR⁵—(CH₂)₂—, —(CH₂)—CHR⁵—(CH₂)₂—,         —(CH₂)₂—O—(CH₂)₂—, —(CH₂)₂—NR⁵—(CH₂)₂—, —(CH₂)₂—CHR⁵—(CH₂)₂—,         —CH₂—O—(CH₂)₃—, —CH₂—NR⁵—(CH₂)₃—, —CH₂—CHR⁵—(CH₂)₃—,

-   R⁵, R¹⁰:     -   alkyl, preferably C₁₋₄-alkyl, such as methyl, ethyl, n-propyl,         isopropyl, n-butyl, isobutyl, sec-butyl and tert-butyl,         preferably methyl and ethyl, more preferably methyl,     -   alkylphenyl, preferably C₇₋₄₀-alkylphenyl, such as         2-methylphenyl, 3-methyl-phenyl, 4-methylphenyl,         2,4-dimethylphenyl, 2,5-dimethylphenyl, 2,6-dimethyl-phenyl,         3,4-dimethylphenyl, 3,5-dimethylphenyl, 2-, 3-, 4-nonylphenyl,         2-, 3-, 4-decylphenyl, 2,3-, 2,4-, 2,5-, 3,4-,         3,5-dinonylphenyl, 2,3-, 2,4-, 2,5-, 3,4- and 3,5-didecylphenyl,         in particular C₇₋₂₀-alkylphenyl,

-   R⁶, R⁷, R⁸, R⁹:     -   methyl or ethyl, preferably methyl,

-   R¹¹, R¹²:     -   alkyl such as C₁- to C₂₀-alkyl, cycloalkyl such as C₃- to         C₁₂-cycloalkyl, aryl, heteroaryl, aralkyl such as C₇— to         C₂₀-aralkyl, and alkylaryl such as C₇- to C₂₀-alkylaryl, in each         case as defined above,

-   X:     -   CH₂, CHR⁵, oxygen (O), sulfur (S) or NR⁵, preferably CH₂ and O,

-   Y:     -   N(R¹⁰)₂, preferably NH₂ and N(CH₃)₂,     -   hydroxyl (OH),     -   C₂₋₂₀-alkylaminoalkyl, preferably C₂₋₁₆-alkylaminoalkyl, such as         methylamino-methyl, 2-methylaminoethyl, ethylaminomethyl,         2-ethylaminoethyl and 2-(iso-propylamino)ethyl,     -   C₃₋₂₀-dialkylaminoalkyl, preferably C₃₋₁₆-dialkylaminoalkyl,         such as dimethylamino-methyl, 2-dimethylaminoethyl,         2-diethylaminoethyl, 2-(di-n-propylamino)ethyl and         2-(diisopropylamino)ethyl,

-   Z:     -   CH₂, CHR⁵, O, NR⁵ or NCH₂CH₂OH,

-   j, l:     -   an integer from 1 to 4 (1, 2, 3 or 4), preferably 2 and 3, more         preferably 2,

-   k, m, q:     -   an integer from 1 to 4 (1, 2, 3 or 4), preferably 2, 3 and 4,         more preferably 2 and 3,

-   n:     -   an integer from 1 to 30, preferably an integer from 1 to 8 (1,         2, 3, 4, 5, 6, 7 or 8), more preferably an integer from 1 to 6.

Suitable alcohols under the abovementioned prerequisites are virtually all primary and secondary alcohols with an aliphatic OH function. The alcohols may be straight-chain, branched or cyclic. Secondary alcohols are aminated just as efficiently as primary alcohols. The alcohols may also bear substituents or comprise functional groups which behave inertly under the conditions of the hydrogenating amination, for example alkoxy, alkenyloxy, alkylamino or dialkylamino groups, or else if appropriate are hydrogenated under the conditions of the hydrogenating amination, for example CC double or triple bonds. When polyhydric alcohols, for example, diols or triols, particularly glycols, are to be aminated, it is possible via the control of the reaction conditions to obtain preferentially amino alcohols, cyclic amines or polyaminated products.

The amination of 1,2-diols leads, depending on the selection of the reaction conditions, particularly to 1-amino-2-hydroxy compounds or 1,2-diamino compounds.

The amination of 1,4-diols leads, depending on the selection of the reaction conditions, to 1-amino-4-hydroxy compounds, 1,4-diamino compounds, or to five-membered rings with a nitrogen atom (pyrrolidines).

The amination of 1,6-diols leads, depending on the selection of the reaction conditions, to 1-amino-6-hydroxy compounds, 1,6-diamino compounds, or to seven-membered rings with a nitrogen atom (hexamethyleneimines).

The amination of 1,5-diols leads, depending on the selection of the reaction conditions, to 1-amino-5-hydroxy, 1,5-diamino compounds, or to six-membered rings with a nitrogen atom (piperidines, 1,5-dipiperidinylpentanes).

It is accordingly possible to obtain from diglycol (DEG), by amination with NH₃, monoaminodiglycol (=ADG=H₂N—CH₂CH₂—O—CH₂CH₂—OH), diaminodiglycol (H₂N—CH₂CH₂—O—CH₂CH₂—NH₂) or morpholine. Particularly preference is given here to ADG as the process product.

Piperazine is correspondingly obtained with particular preference from diethanolamine. N-(2-Hydroxyethyl)piperazine can be obtained from triethanolamine.

Preference is given to aminating, for example, the following alcohols:

methanol, ethanol, n-propanol, isopropanol, n-butanol, isobutanol, n-pentanol, n-hexanol, 2-ethylhexanol, tridecanol, stearyl alcohol, palmityl alcohol, cyclobutanol, cyclopentanol, cyclohexanol, benzyl alcohol, 2-phenylethanol, 2-(p-methoxyphenyl)-ethanol, 2-(3,4-dimethoxyphenyl)ethanol, 1-phenyl-3-butanol, ethanolamine, n-propanolamine, isopropanolamine, 2-amino-1-propanol, 1-methoxy-2-propanol, 3-amino-2,2-dimethyl-1-propanol, n-pentanolamine(1-amino-5-pentanol), n-hexanol-amine (1-amino-6-hexanol), ethanolamine, diethanolamine, triethanolamine, N-alkyl-diethanolamines, diisopropanolamine, 3-(2-hydroxyethylamino)propan-1-ol, 2-(N,N-dimethylamino)ethanol, 2-(N,N-diethylamino)ethanol, 2-(N,N-di-n-propylamino)ethanol, 2-(N,N-diisopropylamino)ethanol, 2-(N,N-di-n-butylamino)ethanol, 2-(N,N-diisobutyl-amino)ethanol, 2-(N,N-di-sec-butylamino)ethanol, 2-(N,N-di-tert-butylamino)ethanol, 3-(N,N-dimethylamino)propanol, 3-(N,N-diethylamino)propanol, 3-(N,N-di-n-propylamino)propanol, 3-(N,N-diisopropylamino)propanol, 3-(N,N-di-n-butylamino)propanol, 3-(N,N-diisobutylamino)propanol, 3-(N,N-di-sec-butylamino)-propanol, 3-(N,N-di-tert-butylamino)propanol, 1-dimethylaminopentanol-4,1-di-ethylaminopentanol-4, ethylene glycol, 1,2-propylene glycol, 1,3-propylene glycol, diglycol, 1,4-butanediol, 1,5-pentanediol, 1,6-hexanediol, 2,2-bis[4-hydroxycyclohexyl]propane, methoxyethanol, propoxyethanol, butoxyethanol, polypropyl alcohols, polyethylene glycol ethers, polypropylene glycol ethers and polybutylene glycol ethers. The latter polyalkylene glycol ethers are converted to the corresponding amines in the inventive reaction by converting their free hydroxyl groups.

Particularly preferred alcohols are methanol, ethanol, n-propanol, i-propanol, n-butanol, sec-butanol, 1,4-butanediol, 1,5-pentanediol, 1,6-hexanediol, 2-ethylhexanol, cyclohexanol, fatty alcohols, ethylene glycol, diethylene glycol (DEG), triethylene glycol (TEG), 2-(2-dimethylaminoethoxy)ethanol, N-methyldiethanolamine and 2-(2-di-methylaminoethoxy)ethanol.

Suitable ketones usable in the process according to the invention are, under the abovementioned prerequisites, virtually all aliphatic and aromatic ketones. The aliphatic ketones may be straight-chain, branched or cyclic; the ketones may comprise heteroatoms. The ketones may further bear substituents or comprise functional groups which behave inertly under the conditions of the hydrogenating amination, for example alkoxy, alkenyloxy, alkylamino or dialkylamino groups, or else, if appropriate, are hydrogenated under the conditions of the hydrogenating amination, for example C—C double or triple bonds. When polyfunctional ketones are to be aminated, it is possible via the control of the reaction conditions to obtain amino ketones, amino alcohols, cyclic amines or polyaminated products.

Preference is given, for example, to aminatingly hydrogenating the following ketones:

acetone, ethyl methyl ketone, methyl vinyl ketone, isobutyl methyl ketone, butanone, 3-methylbutan-2-one, diethyl ketone, tetralone, acetophenone, p-methylacetophenone, p-methoxyacetophenone, m-methoxyacetophenone, 1-acetylnaphthalene, 2-acetyl-naphthalene, 1-phenyl-3-butanone, cyclobutanone, cyclopentanone, cyclopentenone, cyclohexanone, cyclohexenone, 2,6-dimethylcyclohexanone, cycloheptanone, cyclododecanone, acetylacetone, methylglyoxal and benzophenone.

Suitable aldehydes usable in the process according to the invention are, under the abovementioned prerequisites, virtually all aliphatic and aromatic aldehydes. The aliphatic aldehydes may be straight-chain, branched or cyclic; the aldehydes may comprise heteroatoms. The aldehydes may further bear substituents or comprise functional groups which behave inertly under the conditions of the hydrogenating amination, for example alkoxy, alkenyloxy, alkylamino or dialkylamino groups, or else, if appropriate, are hydrogenated under the conditions of the hydrogenating amination, for example C—C double or triple bonds. When polyfunctional aldehydes or keto aldehydes are to be aminated, it is possible via the control of the reaction conditions to obtain amino alcohols, cyclic amines or polyaminated products.

Preference is given, for example, to aminatingly hydrogenating the following aldehydes:

formaldehyde, acetaldehyde, propionaldehyde, n-butyraldehyde, isobutyraldehyde, pivalaldehyde, n-pentanal, n-hexanal, 2-ethylhexanal, 2-methylpentanal, 3-methyl-pentanal, 4-methylpentanal, glyoxal, benzaldehyde, p-methoxybenzaldehyde, p-methylbenzaldehyde, phenylacetaldehyde, (p-methoxyphenyl)acetaldehyde, (3,4-dimethoxyphenyl)acetaldehyde, 4-formyltetrahydropyran, 3-formyltetrahydrofuran, 5-formylvaleronitrile, citronellal, lysmeral, acrolein, methacrolein, ethylacrolein, citral, crotonaldehyde, 3-methoxypropionaldehyde, 3-aminopropionaldehyde, hydroxypivalaldehyde, dimethylolpropionaldehyde, dimethylolbutyraldehyde, furfural, glyoxal, glutaraldehyde and hydroformylated oligomers and polymers, for example hydroformylated polyisobutene (polyisobutenealdehyde) or hydroformylated oligomer obtained by metathesis of 1-pentene and cyclopentene.

The aminating agents used in the hydrogenating amination of alcohols, aldehydes or ketones in the presence of hydrogen may be either ammonia or primary or secondary, aliphatic or cycloaliphatic or aromatic amines.

When the aminating agent used is ammonia, the alcoholic hydroxyl group or the aldehyde group or the keto group is initially converted to the primary amino groups (—NH₂). The primary amine thus formed may react with further alcohol or aldehyde or ketone to give the corresponding secondary amine and this may in turn react with further alcohol or aldehyde or ketone to give the corresponding, preferably symmetrical, tertiary amine. Depending on the composition of the reaction mixture or of the reactant stream (in continuous mode), and depending on the reaction conditions employed—pressure, temperature, reaction time (catalyst hourly space velocity)—it is possible in this way to prepare preferentially primary, secondary or tertiary amines as desired.

In this way, it is possible to prepare, from polyhydric alcohols or di- or oligoaldehydes or di- or oligoketones or keto aldehydes, by intramolecular hydrogenating amination, cyclic amines, for example pyrrolidines, piperidines, hexamethyleneimines, piperazines and morpholines.

As well as ammonia, the aminating agents used may equally be primary or secondary amines.

These aminating agents are preferably used to prepare unsymmetrically substituted di- or trialkylamines, such as ethyldiisopropylamine and ethyldicyclohexylamine. For example the following mono- and dialkylamines are used as aminating agents: monomethylamine, dimethylamine, monoethylamine, diethylamine, n-propylamine, di-n-propylamine, isopropylamine, diisopropylamine, isopropylethylamine, n-butylamine, di-n-butylamine, s-butylamine, di-s-butylamine, isobutylamine, n-pentylamine, s-pentylamine, isopentylamine, n-hexylamine, s-hexylamine, iso-hexylamine, cyclohexylamine, aniline, toluidine, piperidine, morpholine and pyrrolidine.

Amines prepared with particular preference by the process according to the invention are, for example, morpholine (from monoaminodiglycol), monoaminodiglycol, morpholine and/or 2,2′-dimorpholinodiethyl ether (DMDEE) (from DEG and ammonia), 6-dimethylaminohexanol-1 (from hexanediol and dimethylamine (DMA)), triethylamine (from ethanol and diethylamine (DEA)), dimethylethylamine (from ethanol and DMA), N—(C₁₋₄-alkyl)morpholine (from DEG and mono(C₁₋₄-alkyl)amine), N—(C₁₋₄-alkyl)piperidine (from 1,5-pentanediol and mono(C₁₋₄-alkyl)amine), piperazine and/or diethylenetriamine (DETA) (from N-(2-aminoethyl)ethanolamine (AEEA) and ammonia), N-methylpiperazine (from diethanolamine and MMA), N,N″-dimethylpiperazine (from N-methyldiethanolamine and MMA), 1,2-ethylenediamine (EDA) and/or diethylenetriamine (DETA) and/or PIP (from monoethanolamine (MEOA) and ammonia), 2-ethylhexylamine and bis(2-ethylhexyl)amine (from 2-ethylhexanol and NH₃), tridecylamine and bis(tridecyl)amine (from tridecanol and NH₃), n-octylamine (from n-octanol and NH₃), 1,2-propylenediamine (from 2-hydroxypropylamine and NH₃), 1-diethylamino-4-aminopentane (from 1-diethylamino-4-hydroxypentane and NH₃), N,N-di(C₁₋₄-alkyl)cyclohexylamine (from cyclohexanone and/or cyclohexanol and di(C₁₋₄-alkyl)amine), e.g. N,N-dimethyl-N-cyclohexylamine (DMCHA), polyisobuteneamine (PIBA; where, for example, n˜1000) (from polyisobutenaldehyde and NH₃), N,N-diisopropyl-N-ethylamine (Hünig's base) (from N,N-diisopropylamine and acetaldehyde), N-methyl-N-isopropylamine (MMIPA) (from monomethylamine and acetone), n-propylamines (such as mono-/di-n-propylamine, N,N-dimethyl-N-n-propylamine (DMPA)) (from propionaldehyde and/or n-propanol and NH₃ or DMA), N,N-dimethyl-N-isopropylamine (DMIPA) (from i-propanol and/or acetone and DMA), N,N-dimethyl-N-butylamines (1-, 2- or isobutanol and/or butanal, i-butanal or butanone and DMA), 2-(2-di(C₁₋₄-alkyl)aminoethoxy)ethanol and/or bis(2-di(C₁₋₄-alkyl)aminoethyl)ether (from DEG and di(C₁₋₄-alkyl)amine), 1,2-ethylenediamine (EDA), monoethanolamine (MEOA), diethylenetriamine (DETA) and/or piperazine (PIP) (from monoethylene glycol (MEG) and ammonia), 1,8-diamino-3,6-dioxaoctane and/or 1-amino-8-hydroxy-3,6-dioxaoctane (from triethylene glycol (TEG) and ammonia), 1-methoxy-2-propylamine(1-methoxyisopropylamine, MOIPA) (from 1-methoxy-2-propanol and ammonia), N-cyclododecyl-2,6-dimethylmorpholine (dodemorph) (from cyclododecanone and/or cyclododecanol and 2,6-dimethylmorpholine), polyetheramine (from corresponding polyether alcohol and ammonia). The polyether alcohols are, for example, polyethylene glycols or polypropylene glycols having a molecular weight in the range from 200 to 5000 g/mol; the corresponding polyetheramines are obtainable, for example, under the tradename PEA 0230, D400, D2000, T403 or T5000 from BASF.

EXAMPLES Example 1 Preparation of Amination Catalyst 1 (Based on Ni—Co—Cu/ZrO₂=Comparative Experiment According to EP 963 975 A)

An aqueous solution of nickel nitrate, cobalt nitrate, copper nitrate and zirconium acetate which comprised 2.39% by weight of NiO, 2.39% by weight of CoO, 0.94% by weight of CuO and 2.82% by weight of ZrO₂ was precipitated simultaneously in a stirred vessel in a constant stream with a 20% aqueous sodium carbonate solution at a temperature of 70° C. in such a way that the pH, measured with a glass electrode, of 7.0 was maintained. The resulting suspension was filtered and the filtercake was washed with demineralized water until the electrical conductivity of the filtrate was approx. 20 μS. Thereafter, the filtercake was dried at a temperature of 150° C. in a drying cabinet or a spray dryer. The hydroxide-carbonate mixture obtained in this way was then heat-treated at a temperature of from 450 to 500° C. over a period of 4 hours. The catalyst thus prepared had the composition: 28% by weight of NiO, 28% by weight of CoO, 11% by weight of CuO and 33% by weight of ZrO₂. The catalyst was mixed with 3% by weight of graphite and shaped to tablets. The oxidic tablets were reduced. The reduction was performed at 280° C. at a heating rate of 3° C./minute. Reduction was effected first with 10% H₂ in N₂ for 50 minutes, then with 25% H₂ in N₂ for 20 minutes, then with 50% H₂ in N₂ for 10 minutes, then with 75% H₂ in N₂ for 10 minutes and finally with 100% H₂ for 3 hours. The percentages are each % by volume. The passivation of the reduced catalyst was performed at room temperature in dilute air (air in N₂ with a maximum O₂ content of 5% by volume).

Example 2

The catalyst was prepared analogously to catalyst 1. However, the amounts of nickel nitrate, of copper nitrate and of cobalt nitrate were altered accordingly. In addition, iron nitrate was also added to the nitrate solution, so as to obtain the oxide mixture specified below. The catalyst 2 thus obtained had the composition as shown in Table I.

Example 3

The catalyst was prepared analogously to catalyst 2. However, the amounts of nickel nitrate, of copper nitrate, of iron nitrate and of cobalt nitrate were altered accordingly. In addition, lead nitrate was also added to the nitrate solution, so as to obtain the oxide mixture specified below. The catalyst 3 thus obtained had the composition as shown in Table I.

Example 4

The catalyst was prepared analogously to catalyst 2. However, the amounts of nickel nitrate, of copper nitrate, of iron nitrate and of cobalt nitrate were altered accordingly. In addition, tin dichloride was also added to the nitrate solution, so as to obtain the oxide mixture specified below. The catalyst 4 thus obtained had the composition as shown in Table I.

Example 5

The catalyst is prepared analogously to catalyst 2. However, the amounts of nickel nitrate, of copper nitrate, of iron nitrate and of cobalt nitrate were altered accordingly. In addition, antimony oxide dissolved in concentrated aqueous KOH is additionally added to the 20% sodium carbonate solution, so as to obtain the oxide mixture specified below. The catalyst 5 thus obtained had the composition as shown in Table I.

Example 6

The catalyst is prepared analogously to catalyst 2. However, the amounts of nickel nitrate, of copper nitrate, of iron nitrate and of cobalt nitrate were altered accordingly. In addition, bismuth nitrate is also added to the nitrate solution, so as to obtain the oxide mixture specified below. The catalyst 6 thus obtained had the composition as shown in Table I.

Example 7

Amination of Diethylene Glycol (DEG)

10 g of the reduced amination catalyst in the form of approx. 0.2 to 1 mm spall was initially charged in a 300 ml autoclave together with 70 g of diethylene glycol (0.65 mol). 34 g of liquid ammonia (2 mol) were added to the reaction mixture, and the autoclave was injected with hydrogen to 50 bar and heated to 200° C. At 200° C., hydrogen was again injected, and the total pressure rose to 180-200 bar. The autoclave was run at 200° C. for 12 hours with stirring.

At different times, samples of the reaction mixture were taken and analyzed by means of GC chromatography. For this purpose, a 30 m “RTX-5 amine” GC column was used, with a temperature program of: 80° C./15 minutes, heat to 290° C. within 30 minutes, at 290° C./15 minutes.

The composition of the resulting reaction mixtures for the catalysts of Examples 1 to 6 can be taken from Table 1.

TABLE I Performance Total Amination ADG/ selectivity activity** morpholine of MeOEt Catalyst* DEG mmol of Morpholine ratio ADG + normal- Dot. Time conversion DEG/ (MOR) ADG GC %/ MOR MeOEt ized # Ni % Co % Cu % Fe % Dot. % hours GC % gcat · h GC % GC % GC % GC % GC % Σ GC % 1 21.9 21.9 10.5 — — — 2 56.2 1.83 18.2 26.3 1.45 79.2 0.20 0.35 2 29.3 3.4 10.0 2.2 — — 2 51.3 1.66 12.6 27.2 2.16 77.6 0.22 0.43 3 32.5 4.1 9.8 1.0 Pb 1.4 4 48.02 0.94 8.8 32.0 3.62 85.1 0.08 0.17 4 31.0 3.6 10.0 0.7 Sn 2.8 2 47.3 1.54 15.0 23.9 1.59 82.2 0.05 0.11 5 31.0 3.7 9.9 1.1 Sb 0.8 4 49.6 1.18 9.8 30.1 3.07 80.4 0.08 0.17 6 34.0 4.1 10.3 1.1 Bi 0.7 2 63.8 2.08 18.4 31.5 1.71 78.2 0.2 0.31 *Catalyst composition in % by weight; remainder up to 100% by weight is ZrO2 **Amination activity: DEG converted/gcat · h in 2 h sample DEG diethylene glycol MOR morpholine ADG aminodiglycol MeOEt methoxyethanol Workup:

The particular pure products can be obtained from the aqueous crude materials by rectification under reduced pressure, standard pressure or elevated pressure by the known methods. The pure products are obtained either directly in pure form or as azeotropes with water. Aqueous azeotropes can be dewatered by a liquid-liquid extraction with concentrated sodium hydroxide solution before or after the purifying distillation. Distillative dewatering in the presence of an azeotroping agent by known methods is also possible.

In the case that the crude material or the aliphatic amine in the crude material is barely water-miscible, if at all, dewatering is also possible by a separation of the organic and of the aqueous phase by known methods.

Conclusion

The performance of amination catalysts has been significantly improved over the prior art while maintaining the good catalyst activity by altering the chemical composition of the active composition. The yield of linear animation products of economic interest, such as aminodiglycol, has been increased, and the extent of undesired decarbonylation, which is determined by the content of methoxyethanol, has been reduced by establishing specific contents of Fe and specific contents of Sn, Pb, Sb and Bi in the catalyst, in addition to the contents of Cu, Ni, Co. 

1. A catalyst comprising a catalytically active composition which comprises, before reduction with hydrogen, oxygen compounds of zirconium, copper, and nickel, and 0.2 to 40% by weight of an oxygen compound of cobalt, calculated as CoO, 0.1 to 5% by weight of an oxygen compound of iron, calculated as Fe₂O₃, and 0.1 to 5% by weight of at least one oxygen compound of lead, tin, bismuth or antimony, calculated as PbO, SnO, Bi₂O₃ and Sb₂O₃ respectively.
 2. A process for preparing an amine, the process comprising: reacting a reactant selected from the group consisting of primary alcohols, secondary alcohols, aldehydes, ketones, and mixtures thereof, with hydrogen and a nitrogen compound selected from the group consisting of ammonia, primary amines, secondary amines and mixtures thereof, in the presence of a zirconium dioxide-, copper- and nickel-containing catalyst; wherein the catalyst comprises a catalytically active composition which comprises, before reduction with hydrogen, oxygen compounds of zirconium, copper, and nickel, and 0.2 to 40% by weight of an oxygen compound of cobalt, calculated as CoO, 0.1 to 5% by weight of an oxygen compound of iron, calculated as Fe₂O₃, and 0.1 to 5% by weight of at least one oxygen compound of lead, tin, bismuth or antimony, calculated as PbO, SnO, Bi₂O₃ and Sb₂O₃ respectively.
 3. The process according to claim 2, wherein the catalytically active composition of the catalyst, before reduction with hydrogen, comprises 0.3 to 4.5% by weight of the at least one oxygen compound of lead, tin, bismuth or antimony.
 4. The process according to claim 2, wherein the catalytically active composition of the catalyst, before reduction with hydrogen, comprises 0.5 to 4% by weight of the at least one oxygen compound of lead, tin, bismuth or antimony.
 5. The process according to claim 2, wherein the catalytically active composition of the catalyst, before reduction with hydrogen, comprises 0.2 to 4% by weight of an oxygen compound of iron, calculated as Fe₂O₃.
 6. The process according to claim 2, wherein the catalytically active composition of the catalyst, before reduction with hydrogen, comprises 0.5 to 3% by weight of an oxygen compound of iron, calculated as Fe₂O₃.
 7. The process according to claim 2, wherein the catalytically active composition of the catalyst, before reduction with hydrogen, comprises 1 to 25% by weight of an oxygen compound of cobalt, calculated as CoO.
 8. The process according to claim 2, wherein the catalytically active composition of the catalyst, before reduction with hydrogen, comprises 2 to 10% by weight of an oxygen compound of cobalt, calculated as CoO.
 9. The process according to claim 2, wherein the catalytically active composition of the catalyst, before reduction with hydrogen, comprises 20 to 85% by weight of an oxygen compound of zirconium, calculated as ZrO₂, 0.2 to 25% by weight of an oxygen compound of copper, calculated as CuO, and 0.2 to 45% by weight of an oxygen compound of nickel, calculated as NiO.
 10. The process according to claim 2, wherein the catalytically active composition of the catalyst, before reduction with hydrogen, comprises 25 to 70% by weight of an oxygen compound of zirconium, calculated as ZrO₂, 3 to 20% by weight of an oxygen compound of copper, calculated as CuO, and 10 to 40% by weight of an oxygen compound of nickel, calculated as NiO.
 11. The process according to claim 2, wherein the catalytically active composition of the catalyst, before reduction with hydrogen, comprises 30 to 60% by weight of an oxygen compound of zirconium, calculated as ZrO₂, 5 to 15% by weight of an oxygen compound of copper, calculated as CuO, and 25 to 35% by weight of an oxygen compound of nickel, calculated as NiO.
 12. The process according to claim 2, wherein the catalytically active composition of the catalyst, before reduction with hydrogen, comprises 2 to 10% by weight of an oxygen compound of cobalt, calculated as CoO, and 0.1 to 5.0% by weight of an oxygen compound of lead, calculated as PbO.
 13. The process according to claim 2, wherein nickel and copper are present in the catalyst in a molar ratio of nickel to copper of greater than
 1. 14. The process according to claim 2, wherein the catalytically active composition does not comprise any rhenium and/or ruthenium.
 15. The process according to claim 2, wherein the catalytically active composition does not comprise any zinc.
 16. The process according to claim 2, wherein the catalytically active composition does not comprise any silver and/or molybdenum.
 17. The process according to claim 2, wherein the catalytically active composition does not comprise any further catalytically active component.
 18. The process according to claim 2, wherein the reaction is carried out at a temperature of 80 to 350° C.
 19. The process according to claim 2, wherein the reaction is carried out in liquid phase at an absolute pressure of 5 to 30 MPa or in gas phase at an absolute pressure of 0.1 to 40 MPa.
 20. The process according to claim 2, wherein the nitrogen compound is reacted in a molar amount of 0.90 to 100 times the molar amount of the reactant selected from the group consisting of primary alcohols, secondary alcohols, aldehydes, ketones, and mixtures thereof.
 21. The process according to claim 2, wherein the nitrogen compound is reacted in a molar amount of 1.0 to 10 times the molar amount of the reactant selected from the group consisting of primary alcohols, secondary alcohols, aldehydes, ketones, and mixtures thereof.
 22. The process according to claim 2, wherein the catalyst is arranged in the reactor as a fixed bed.
 23. The process according to claim 2, wherein the reaction is carried out continuously.
 24. The process according to claim 23, wherein the reaction is carried out in a tubular reactor.
 25. The process according to claim 23, wherein the reaction is carried out in a cycle gas method.
 26. The process according to claim 2, wherein the reactant selected from the group consisting of primary alcohols, secondary alcohols, aldehydes, ketones, and mixtures thereof is an aqueous solution.
 27. The process according to claim 2, wherein the nitrogen compound is an aqueous solution.
 28. The process according to claim 2, wherein the reactant selected from the group consisting of primary alcohols, secondary alcohols, aldehydes, ketones, and mixtures thereof comprises diethylene glycol (DEG) and the nitrogen compound comprises ammonia, for preparing monoaminodiglycol (ADG) and morpholine.
 29. The process according to claim 2, wherein the reactant selected from the group consisting of primary alcohols, secondary alcohols, aldehydes, ketones, and mixtures thereof comprises diethylene glycol (DEG) and the nitrogen compound comprises a mono(C₁₋₄-alkyl)amine, for preparing an N—(C₁₋₄-alkyl)morpholine.
 30. The process according to claim 2, wherein the reactant selected from the group consisting of primary alcohols, secondary alcohols, aldehydes, ketones, and mixtures thereof comprises diethylene glycol (DEG) and the nitrogen compound comprises a di(C₁₋₄-alkyl)amine, for preparing a 2-(2-di(C₁₋₄alkyl)aminoethoxy)ethanol and/or a bis(2-di(C₁₋₄-alkyl)aminoethyl) ether.
 31. The process according to claim 2, wherein the reactant selected from the group consisting of primary alcohols, secondary alcohols, aldehydes, ketones, and mixtures thereof comprises monoethylene glycol (MEG) and the nitrogen compound comprises ammonia, for preparing monoethanolamine (MEOA) and/or 1,2-ethylenediamine (EDA).
 32. The process according to claim 2, wherein the reactant selected from the group consisting of primary alcohols, secondary alcohols, aldehydes, ketones, and mixtures thereof comprises monoethanolamine (MEOA) and the nitrogen compound comprises ammonia, for preparing 1,2-ethylenediamine (EDA).
 33. The process according to claim 2, wherein the reactant selected from the group consisting of primary alcohols, secondary alcohols, aldehydes, ketones, and mixtures thereof comprises a polyether alcohol and the nitrogen compound comprises ammonia, for preparing a corresponding polyetheramine.
 34. The process according to claim 2, wherein the reactant selected from the group consisting of primary alcohols, secondary alcohols, aldehydes, ketones, and mixtures thereof comprises N-(2-aminoethyl)ethanolamine (AEEA) and the nitrogen compound comprises ammonia, for preparing piperazine and/or diethylenetriamine (DETA).
 35. The process according to claim 2, wherein the reactant selected from the group consisting of primary alcohols, secondary alcohols, aldehydes, ketones, and mixtures thereof comprises polyisobutenaldehyde and the nitrogen compound comprises ammonia, for preparing polyisobutenamine (PIBA). 